Like his younger sister Sarah, Charles Lenox was inspired to fight for freedom by their parents John and Nancy Remond. Charles traveled as a promoter of the abolitionist paper, The Liberator. In 1833 he became an officer of the New England Anti-Slavery Society. He traveled to London for the World Anti-Slavery Convention and toured the British Isles lecturing about abolition. When he returned to the United States he began working with Frederick Douglass. The two would continue to work together intermittently through the Civil War.